Referenced in: none

Automatically associated channels: ClC4

Title: [Correlation of aquaporin 3 expression with the clinicopathologic characteristics of non-small cell lung cancer].

Authors: Bailing Li, Lei Jin, Keng Zhong, Dahai Du

Journal, date & volume: Zhongguo Fei Ai Za Zhi, 2012 Jul 20 , 15, 404-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22814259

Abstract
Lung cancer is a major health problem worldwide. The aim of this study is to investigate aquaporin 3 (AQP3) expression and its relationship with the clinicopathologic characteristics of non-small cell lung cancer (NSCLC).AQP3 expression and the microvascular density (MVD) of tissue samples from 180 cases with NSCLC were detected by immunohistochemistry.AQP3 expression was negative in 25 (13.9%), positive in 67 (37.2%), and strongly positive in 88 (48.9%) of the 180 cases, which was significantly higher than that in the normal tissue (P<0.01). A significant correlation was found between AQP3 expression and MVD (P<0.01), whereas a high MVD was found among patients with strongly positive AQP3 expression. Male patients with positive or strongly positive AQP3 expression had significantly higher expression than female patients did (P=0.003). AQP3 expression was more significantly enhanced in adenocarcinoma than that in squamous cell carcinoma (P<0.001). Statistical analysis indicated that the positive rate of AQP3 expression in well-differentiated carcinoma was significantly higher than that in poorly differentiated tumors (P<0.001). Lymph node metastasis was positively correlated with high AQP3 expression (P=0.026).AQP3 expression was closely correlated with MVD in NSCLC, whereas high MVD was frequently found in tumors with high AQP3 expression. AQP3, as a therapeutic target for inhibiting high AQP3 expression in NSCLC tissues, may weaken cancer cell proliferation, invasion, and metastasis.肺癌是严重威胁人类生存和发展的恶性疾病之一，本研究旨在探讨非小细胞肺癌（non-small cell lung cancer, NSCLC）组织中水通道蛋白-3（aquaporins 3, AQP3）的表达，探讨其与NSCLC临床病理学之间的关系。应用免疫组织化学方法检测180例NSCLC组织中AQP3表达及微血管密度（micro vascular density, MVD）。NSCLC组织中AQP3阴性表达率为13.9%（25/180），中等强度阳性表达率为37.2%（67/180），强阳性表达率为48.9%（88/180）。NSCLC组织中AQP3表达高于癌旁组织，有明显统计学差异（P < 0.01）。AQP3高表达也同时伴随着MVD计数增高（P < 0.01）。男性患者AQP3表达高于女性患者（P=0.003）。腺癌中AQP3的表达较鳞癌明显增强（P < 0.001）；有淋巴结转移的病例存在AQP3高表达（P=0.026）。NSCLC中AQP3的阳性表达率与肿瘤分化程度呈正相关，表现为AQP3的阳性表达率在高分化癌中明显高于低分化癌（P < 0.001）。AQP3在NSCLC的肿瘤血管生成和进展中起重要促进作用，AQP3可能为NSCLC治疗的新靶点。