Channelpedia

PubMed 22972391


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPA , TRPA1 , TRPM , TRPM4 , TRPV , TRPV1



Title: Transient Receptor Potentials (TRPs) and Anaphylaxis.

Authors: Peter K Smith, Bernd Nilius

Journal, date & volume: Curr Allergy Asthma Rep, 2013 Feb , 13, 93-100

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22972391


Abstract
The transient receptor potential (TRP) superfamily consists of 28 members in mammals (27 in human) that act as polymodal sensors and ion channels. They regulate cellular calcium influx, generate depolarization thereby triggering voltage dependent cellular processes, and in turn they are critical in inducing the metabolic activities of cells. It is increasingly apparent that many of the inflammatory mediators released in allergic reactions involve at least two of these ion channels, the 'Vanilloid' TRPV1 and the 'Ankyrin" TRPA1. This review mainly focuses on TRPV1 and TRPA1 and the role they have in the allergic response and how these receptors may be influenced in exercise-induced anaphylaxis. The threshold to react to an allergen for mast cells and lymphocytes can be reduced by activating the melastatin channel TRPM4. This channel is briefly discussed in the context of allergy.