Referenced in: Kv10.1

Automatically associated channels: Kv10.1 , Kv6.3

Title: Physical and functional interaction of K(V)10.1 with Rabaptin-5 impacts ion channel trafficking.

Authors: Milena Ninkovic, Mišo Mitkovski, Tobias Kohl, Walter Stühmer, Luis A Pardo

Journal, date & volume: FEBS Lett., 2012 Jul 25 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22841712

Abstract
K(V)10.1 is a potassium channel expressed in brain and implicated in tumor progression. We have searched for proteins interacting with K(V)10.1 and identified Rabaptin-5, an effector of the Rab5 GTPase. Both proteins co-localize on large early endosomes induced by Rab5 hyperactivity. Silencing of Rabaptin-5 induces down-regulation of recycling of K(V)10.1 channel in transfected cells and reduction of K(V)10.1 current density in cells natively expressing K(V)10.1, indicating a role of Rabaptin-5 in channel trafficking. K(V)10.1 co-localizes, but does not physically interact, with Rab7 and Rab11. Our data highlights the complex control of the amount of K(V)10.1 channels on the cell surface.