PubMed 22264780

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Automatically associated channels: Kir1.1 , Kir6.2

Title: Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.

Authors: Beatriz Tavira, Eliecer Coto, Armando Torres, Carmen Díaz-Corte, Beatriz Díaz-Molina, Francisco Ortega, Manuel Arias, Juan M Díaz, Rafael Selgas, Carlos López-Larrea, Marta Ruiz-Ortega, Alberto Ortiz, Elena González, Josep M Campistol, Victoria Alvarez,

Journal, date & volume: Mol. Genet. Metab., 2012 Mar , 105, 525-7

PubMed link:

KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association.