Referenced in: none

Automatically associated channels: TRP , TRPC , TRPC1

Title: Silencing TRPC1 expression inhibits invasion of CNE2 nasopharyngeal tumor cells.

Authors: Benfu He, Feiye Liu, Jian Ruan, Aimin Li, Jinzhang Chen, Rong Li, Jie Shen, Dayong Zheng, Rongcheng Luo

Journal, date & volume: Oncol. Rep., 2012 May , 27, 1548-54

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22367186

Abstract
The invasion and metastasis processes involved in nasopharyngeal carcinoma (NPC) remain enigmatic. Transient receptor potential channel-related protein 1 (TRPC1) is a cation channel involved in diverse cellular functions by precisely controlling Ca2+. The role of this unique TRPC member in nasopharyngeal malignancies has not yet been delineated. Here, we downregulated TRPC1 in CNE2 cells by RNAi technology and by using 2-APB, an inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor and of store-operated Ca2+ channel-mediated Ca2+ entry. Both types of TRPC1 inhibition resulted in significantly attenuated adhesive and invasive abilities, suggesting that TRPC1 can modulate the metastasis of NPC. These findings support further investigation of the potential of TRPC1 as a novel therapeutic target for intervention in nasopharyngeal carcinoma.