Channelpedia

PubMed 21671872


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPA , TRPA1



Title: Transient receptor potential A1 modulators.

Authors: Tim Strassmaier, Rajagopal Bakthavatchalam

Journal, date & volume: Curr Top Med Chem, 2011 , 11, 2227-36

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21671872


Abstract
TRPA1 is a member of a superfamily of non-selective cation channels that is known to be involved in multiple physiological functions. TRPA1 is activated by a broad spectrum of chemical irritants and endogenous inflammatory compounds. An emerging role for TRPA1 in mediating pain and inflammation raises the possibility that compounds targeting TRPA1 might have significant therapeutic potential. This review discusses the broad classes of molecules that are known to act as agonists and antagonists of TRPA1 towards the aim of providing an overview of the structure and activity of TRPA1 modulators.