PubMed 22122651

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Automatically associated channels: Kir2.3

Title: Case-control association study of GRIA1, GRIA2 and GRIA4 polymorphisms in bipolar disorder.

Authors: Alberto Chiesa, Concetta Crisafulli, Stefano Porcelli, Beatrice Balzarro, Changsu Han, Ashwin A Patkar, Soo-Jung Lee, Moon Ho Park, Chi-Un Pae, Alessandro Serretti

Journal, date & volume: Int J Psychiatry Clin Pract, 2012 Mar , 16, 18-26

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The present study aimed to investigate whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with bipolar disorder (BD) and they could predict clinical outcomes in in-patients with BD treated with mood stabilizers.One hundred and thirty-two (132) patients with BD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures including Young Mania Rating Scale for patients with BD were recorded. Statistical significance was set at the 0.005 level in order to reduce the likelihood of false positive results.We failed to show an evidence for a possible association of GRIA1, GRIA2 and GRIA4 with BD patients, in terms of influences on diagnosis and treatment outcomes, although this was the first study to explore the influence of such genes for bipolar disorder.Our results suggest that 17 SNPs within GRIA1, GRIA2 and GRIA4 may not be associated with the development and treatment outcomes in BD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions.