PubMed 22354173

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv10.1

Title: Popeye proteins: muscle for the aging sinus node.

Authors: Bastiaan J Boukens, Vincent M Christoffels

Journal, date & volume: J. Clin. Invest., 2012 Mar 1 , 122, 810-3

PubMed link:

The electrical impulses that dictate the rhythm of the heartbeat in normal situations and during exercise or stress are initiated by a small number of sinus node pacemaker cells. Senescence and dysfunction of the sinus node affects many people later in life, causing physiologically inappropriate heart rates, but the underlying mechanisms are not well understood. In this issue of the JCI, Froese and colleagues show that deficiency in either Popeye domain containing 1 (Popdc1) or Popdc2 leads to sinus node dysfunction under stressed conditions in aged mice. The mechanism reported to underlie the effects of Popdc1/2 deficiency in mice may cause the stress-induced sinus node dysfunction found in many aged individuals and may point to new strategies for therapeutic intervention.