PubMed 20087888

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.4 , Kv3.1 , Kv4.2

Title: Dendritic mechanisms controlling the threshold and timing requirement of synaptic plasticity.

Authors: Cuiping Zhao, Lang Wang, Theoden Netoff, Li-Lian Yuan

Journal, date & volume: Hippocampus, 2011 Mar , 21, 288-97

PubMed link:

Active conductances located and operating on neuronal dendrites are expected to regulate synaptic integration and plasticity. We investigate how Kv4.2-mediated A-type K(+) channels and Ca(2+) -activated K(+) channels are involved in the induction process of Hebbian-type plasticity that requires correlated pre- and postsynaptic activities. In CA1 pyramidal neurons, robust long-term potentiation (LTP) induced by a theta burst pairing protocol usually occurred within a narrow window during which incoming synaptic potentials coincided with postsynaptic depolarization. Elimination of dendritic A-type K(+) currents in Kv4.2(-/-) mice, however, resulted in an expanded time window, making the induction of synaptic potentiation less dependent on the temporal relation of pre- and postsynaptic activity. For the other type of synaptic plasticity, long-term depression, the threshold was significantly increased in Kv4.2(-/-) mice. This shift in depression threshold was restored to normal when the appropriate amount of internal free calcium was chelated during induction. In concert with A-type channels, Ca(2+) -activated K(+) channels also exerted a sliding effect on synaptic plasticity. Blocking these channels in Kv4.2(-/-) mice resulted in an even larger potentiation while by contrast, the depression threshold was shifted further. In conclusion, dendritic A-type and Ca(2+) -activated K(+) channels dually regulate the timing-dependence and thresholds of synaptic plasticity in an additive way.