Referenced in: none

Automatically associated channels: TRP , TRPC , TRPC6

Title: The possible role of TRPC6 in atopic dermatitis.

Authors: Xiao-Dong Sun, Yang You, Li Zhang, Song Zheng, Yuxiao Hong, Jie Li, Xing-Hua Gao

Journal, date & volume: Med. Hypotheses, 2012 Jan , 78, 42-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22000711

Abstract
Skin barrier dysfunction is involved in the pathogenesis of atopic dermatitis (AD). The impaired barrier function is related to disturbed keratinocyte differentiation through improper Ca2+-regulated pathway in AD. Transient receptor potential canonical (subtype) 6 (TRPC6) is a Ca2+-permeable nonselective cation channel expressed in keratinocytes. TRPC6 contributes to the process of keratinocyte differentiation by regulating Ca2+ influx. Furthermore, TRPC6 alone is considered to be sufficient for nearly full physiological response of keratinocyte differentiation. Until now, the correlation between TRPC6 and AD has not been investigated. We hypothesize that dysfunction of TRPC6 may trigger the process of AD, and that restoring or enhancing the activity of TRPC6 may serve as a new modality in treating AD.