Referenced in: none

Automatically associated channels: Cav3.1 , Cav3.2 , Cav3.3

Title: T-type calcium channel blockers - new and notable.

Authors: L'ubica Lacinová

Journal, date & volume: Gen. Physiol. Biophys., 2011 Dec , 30, 403-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22131323

Abstract
Since cloning of the T-type or Ca(V)3.n calcium channel family in 1998-1999 much progress was made in investigation of their regulation. Most effective metal Ca(V)3 channel blockers are trivalent cations from lanthanide group together with transition metals La(3+) and Y(3+). Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel. Dihydropyridines and phenylalkylamines in addition to block of L-type calcium channel can inhibit Ca(V)3 channels in clinically relevant concentration.