Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Polymodal activation of the endocannabinoid system in the extended amygdala.

Authors: Nagore Puente, Yihui Cui, Olivier Lassalle, Mathieu Lafourcade, François Georges, Laurent Venance, Pedro Grandes, Olivier J Manzoni

Journal, date & volume: Nat. Neurosci., 2011 Dec , 14, 1542-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22057189

Abstract
The reason why neurons synthesize more than one endocannabinoid (eCB) and how this is involved in the regulation of synaptic plasticity in a single neuron is not known. We found that 2-arachidonoylglycerol (2-AG) and anandamide mediate different forms of plasticity in the extended amygdala of rats. Dendritic L-type Ca(2+) channels and the subsequent release of 2-AG acting on presynaptic CB1 receptors triggered retrograde short-term depression. Long-term depression was mediated by postsynaptic mGluR5-dependent release of anandamide acting on postsynaptic TRPV1 receptors. In contrast, 2-AG/CB1R-mediated retrograde signaling mediated both forms of plasticity in the striatum. These data illustrate how the eCB system can function as a polymodal signal integrator to allow the diversification of synaptic plasticity in a single neuron.