Channelpedia

PubMed 22282803


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv10.1



Title: Repeatability and contingency in the evolution of a key innovation in phage lambda.

Authors: Justin R Meyer, Devin T Dobias, Joshua S Weitz, Jeffrey E Barrick, Ryan T Quick, Richard E Lenski

Journal, date & volume: Science, 2012 Jan 27 , 335, 428-32

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22282803


Abstract
The processes responsible for the evolution of key innovations, whereby lineages acquire qualitatively new functions that expand their ecological opportunities, remain poorly understood. We examined how a virus, bacteriophage λ, evolved to infect its host, Escherichia coli, through a novel pathway. Natural selection promoted the fixation of mutations in the virus's host-recognition protein, J, that improved fitness on the original receptor, LamB, and set the stage for other mutations that allowed infection through a new receptor, OmpF. These viral mutations arose after the host evolved reduced expression of LamB, whereas certain other host mutations prevented the phage from evolving the new function. This study shows the complex interplay between genomic processes and ecological conditions that favor the emergence of evolutionary innovations.