Referenced in: none

Automatically associated channels: Kv10.1

Title: Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells.

Authors: Marzieh Zonouzi, Massimiliano Renzi, Mark Farrant, Stuart G Cull-Candy

Journal, date & volume: Nat. Neurosci., 2011 Nov , 14, 1430-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21983683

Abstract
Oligodendrocyte precursor cells (OPCs), a major glial cell type that gives rise to myelinating oligodendrocytes in the CNS, express calcium-permeable AMPA receptors (CP-AMPARs). Although CP-AMPARs are important for OPC proliferation and neuron-glia signaling, they render OPCs susceptible to ischemic damage in early development. We identified factors controlling the dynamic regulation of AMPAR subtypes in OPCs from rat optic nerve and mouse cerebellar cortex. We found that activation of group 1 mGluRs drove an increase in the proportion of CP-AMPARs, reflected by an increase in single-channel conductance and inward rectification. This plasticity required the elevation of intracellular calcium and used PI3K, PICK-1 and the JNK pathway. In white matter, neurons and astrocytes release both ATP and glutamate. Unexpectedly, activation of purinergic receptors in OPCs decreased CP-AMPAR expression, suggesting a capacity for homeostatic regulation. Finally, we found that stargazin-related transmembrane AMPAR regulatory proteins, which are critical for AMPAR surface expression in neurons, regulate CP-AMPAR plasticity in OPCs.