PubMed 18849655

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPC , TRPC3 , TRPC6 , TRPC7

Title: TRPC3/6/7: Topical aspects of biophysics and pathophysiology.

Authors: Petra Eder, Klaus Groschner

Journal, date & volume: Channels (Austin), 2008 Mar-Apr , 2, 94-9

PubMed link:

Nonselective and lipid-regulated cation channels formed by TRPC3, TRPC6 and TRPC7 have recently obtained attention in view their potential pathophysiological impact. It appears as a particular challenge to understand the molecular basis of TRPC3/6/7-related diseases in order to further delineate their value as therapeutic targets. The multifunctional nature of these channel proteins, based on a complex, versatile heteromerization potential along with highly promiscuous gating and mixed cation permeation properties, make these channels pivotal players in cellular signaling networks. Here we summarize newsworthy aspects of TRPC3/6/7 physiology and pathophysiology that open the view on novel therapeutic strategies based on these TRPCs as target structures.