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PubMed 20386566


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Automatically associated channels: cacnb2



Title: Genome-wide association study of bipolar I disorder in the Han Chinese population.

Authors: M T M Lee, C H Chen, C S Lee, C C Chen, M Y Chong, W C Ouyang, N Y Chiu, L J Chuo, C Y Chen, H K L Tan, H Y Lane, T J Chang, C H Lin, S H Jou, Y M Hou, J Feng, T J Lai, C L Tung, T J Chen, C J Chang, F W Lung, C K Chen, I S Shiah, C Y Liu, P R Teng, K H Chen, L J Shen, C S Cheng, T P Chang, C F Li, C H Chou, K H T Wang, C S J Fann, J Y Wu, Y T Chen, A T A Cheng

Journal, date & volume: Mol. Psychiatry, 2011 May , 16, 548-56

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20386566


Abstract
We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10(-7) (rs2709736) and 6.05 × 10(-6) (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P=9.74 × 10(-6)) and in CACNB2 (Calcium channel, voltage-dependent, β-2 subunit) gene (rs11013860, P=5.15 × 10(-5)), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.