Referenced in: none

Automatically associated channels: TRP , TRPC , TRPC6

Title: TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease.

Authors: Shafic El Hindi, Jochen Reiser

Journal, date & volume: Pediatr. Nephrol., 2011 Jul , 26, 1057-64

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21161284

Abstract
Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes.