Referenced in: none

Automatically associated channels: SK3 , TRP

Title: Phosphorylation, protein kinases and ADPKD.

Authors: Xiaohong Li

Journal, date & volume: Biochim. Biophys. Acta, 2011 Oct , 1812, 1219-24

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21392577

Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized by renal cyst formation and caused by mutations in the PKD1 and PKD2 genes, which encode polycystin-1(PC-1) and -2 (PC-2) proteins, respectively. PC-1 is a large plasma membrane receptor involved in the regulation of several biological functions and signaling pathways including the Wnt cascade, AP-1, PI3kinase/Akt, GSK3β, STAT6, Calcineurin/NFAT and the ERK and mTOR cascades. PC-2 is a calcium channel of the TRP family. The two proteins form a functional complex and prevent cyst formation, but the precise mechanism(s) involved remains unknown. This article is part of a Special Issue entitled: Polycystic Kidney Disease.