Referenced in: none

Automatically associated channels: Kir2.3 , Nav1.3 , Nav1.7

Title: Refractory neonatal epilepsy with a de novo duplication of chromosome 2q24.2q24.3.

Authors: Akihisa Okumura, Toshiyuki Yamamoto, Keiko Shimojima, Yoshinobu Honda, Shinpei Abe, Mitsuru Ikeno, Toshiaki Shimizu

Journal, date & volume: Epilepsia, 2011 Jul , 52, e66-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21692795

Abstract
There are only two reports on epileptic patients associated with microduplication of 2q. We found a de novo duplication of chromosome 2q24.2q24.3 in another infant with neonatal epilepsy. The patient had refractory focal seizures since the third day of life. Her seizures were refractory against phenobarbital and levetiracetam, but were controlled by valproate. Array comparative genomic hybridization revealed a 5.3-Mb duplication of 2q24.2q24.3, where at least 22 genes including a cluster of voltage-gated sodium channel genes (SCN1A, SCN2A, SCN3A, SCN7A, and SCN9A) and one noncoding RNA are located.