Channelpedia

PubMed 21822269


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav1.3



Title: Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells.

Authors: Frederick D Gregory, Keith E Bryan, Tina Pangrsic, Irina E Calin-Jageman, Tobias Moser, Amy Lee

Journal, date & volume: Nat. Neurosci., 2011 Sep , 14, 1109-11

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21822269


Abstract
Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.