Referenced in: none

Automatically associated channels: Cav3.1 , Slo1

Title: Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.

Authors: Wei Li, Shu-Lan Zhang, Ning Wang, Bin-Bin Zhang, Ming Li

Journal, date & volume: Cancer Invest., 2011 Jun , 29, 339-46

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21438841

Abstract
Regulation of Ca(2+) channels has been implicated in the progression of tumor cells. We report here that T-type Ca(2+) channel expression in human ovarian cancer tissues is greatly increased compared to normal ovarian tissues. Blockade of T-type Ca(2+) channel with NNC 55-0396, mibefradil, or by specifically knocking down the expression of these proteins with siRNA-Ca(v)3.1/3.2 suppressed the proliferation of two ovarian cancer cell lines and increased G0/G1 phase distribution in the cell cycle. Furthermore, NNC 55-0396 slowed ovarian cancer formation in nude mice. Therefore the function of T-type Ca(2+) channels is important for the proliferation of human ovarian cancer cells.