Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM2

Title: TRPM2 and pancreatic β-cell responses to oxidative stress.

Authors: Andrew M Scharenberg

Journal, date & volume: Islets, 2009 Sep-Oct , 1, 165-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21099268

Abstract
Recent reports have linked the adenine nucleotide 2nd messenger gated Ca (2+) channel TRPM2 with hydrogen peroxide-induced pancreatic β-cell death in mouse and rat systems. As β-cells are exposed in vivo to reactive oxygen species produced via the respiratory chain and NADPH oxidases (reviewed in (3, 4) ), these reports suggest the existence of a TRPM2-dependent signaling pathway involved in β-cell responses to redox stress.