Channelpedia

PubMed 21460418


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav3.1



Title: Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques.

Authors: Kee Hyun Choi, Chiman Song, Chan S Cheong, Hyewhon Rhim

Journal, date & volume: Gen. Physiol. Biophys., 2011 Mar , 30, 100-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21460418


Abstract
T-type calcium channels are involved in a variety of physiological and pathophysiological processes, and thus could be therapeutic targets. However, there is no T-type channel selective blocker for use in clinical practice, demanding a need for the development of novel drugs where a higher-throughput screening system is required. Here we present pharmacological studies on Ca(v)3.1 T-type channels using automated patch-clamp. The IC(50) values obtained from automated patch-clamp and conventional one showed a good correlation (correlation coefficient of 0.82), suggesting that the automated patch-clamp is an efficient and reliable method for ranking the drug potencies for T-type channels.