Referenced in: none

Automatically associated channels: Kir6.1

Title: An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.

Authors: Abdelilah Arredouani, A Mark Evans, Jianjie Ma, John Parrington, Michael X Zhu, Antony Galione

Journal, date & volume: Islets, 2010 Sep-Oct , 2, 323-30

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21099331

Abstract
Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.