Referenced in: none

Automatically associated channels: TRP , TRPP , TRPP1 , TRPP2 , TRPP3

Title: [TRPP subfamily and kidney diseases].

Authors: Jie Zhao, Wei Yang, Jian-Hong Luo

Journal, date & volume: Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010 Nov , 39, 650-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21166062

Abstract
TRPP subfamily is an important member of transient receptor potential family. It has six transmembrane (TM) domains, a large extracellular loop between the first and second TM and 2-4 ankyrin repeats in the N terminal. TRPP subfamily includes TRPP2, TRPP3, TRPP5 etc. There are several differences in their structure, activation mode and function. TRPP subfamily is involved in many physiological mechanisms and its abnormal structure can lead to the formation of polycystic kidney. This subfamily is also closely related to gustation. In this review, we summarize recent research findings of TRPP subfamily and its association with polycystic kidney diseases.