Channelpedia

PubMed 19575990


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Nav1.8 , Nav1.9 , Slo1



Title: [Nav1.8 and Nav1.9 mRNA expression in rat trigeminal ganglion at different interval after molar extraction].

Authors: Lei Zhang, Hong-chen Liu, Dong-sheng Wang

Journal, date & volume: Zhonghua Kou Qiang Yi Xue Za Zhi, 2009 May , 44, 301-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19575990


Abstract
To observe the expression and function of extraction.Real-time reverse transcription PCR paralleled with vitro-established cRNA standard curves was applied to measure the expression of Nav1.8, Nav1.9 at 30 min, 2 h, 1 d, 3 d and 6 d respectively after extraction of rat right mandibular molars. The right mandibular molars were used as control.Both Nav1.8 and Nav1.9 mRNA in right trigeminal ganglion showed little change after 30 min, and increased slowly after 2 h. Nav1.8, Nav1.9 mRNA expressions increased by 27% and 24.5% respectively compared to the left trigeminal ganglion after 3 d, reaching the highest level (P < 0.05), and then the expressions began decreasing from 6 d.The pain caused by molar extraction is related to the up-regulation of expressions of sodium channels protein Nav1.8 and Nav1.9 mRNA, indicating the participation of sodium channels in regulations of peripheral tissue pain after molar extraction.