PubMed 20956091

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Automatically associated channels: Kir3.2 , Kir6.2

Title: High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease.

Authors: Joyce E Yu, Suk See De Ravin, Gulbu Uzel, Carol Landers, Stephan Targan, Harry L Malech, Steven M Holland, Wenqing Cao, Noam Harpaz, Lloyd Mayer, Charlotte Cunningham-Rundles

Journal, date & volume: Clin. Immunol., 2011 Jan , 138, 14-22

PubMed link:

Chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD) have overlapping gastrointestinal manifestations. Serum antibodies to intestinal microbial antigens in IBD are thought to reflect a loss of tolerance in the setting of genetically encoded innate immune defects. CGD subjects studied here, with or without colitis, had considerably higher levels of ASCA IgA, ASCA IgG, anti-OmpC, anti-I2, and anti-CBir1, but absent to low pANCA, compared to IBD-predictive cutoffs. Higher antibody levels were not associated with a history of colitis. Except for higher ASCA IgG in subjects <18 years, antibody levels were not age-dependent. In comparison, 7 HIES subjects expressed negative to low antibody levels to all of these antigens; none had colitis. Our results suggest that markedly elevated levels of antimicrobial antibodies in CGD do not correlate with a history of colitis but may reflect a specific defect in innate immunity in the face of chronic antigenic stimulation.