Channelpedia

PubMed 20682332


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: BK , Slo1



Title: Cloning and distribution of Ca2+-activated K+ channels in lobster Panulirus interruptus.

Authors: Q Ouyang, V Patel, J Vanderburgh, R M Harris-Warrick

Journal, date & volume: Neuroscience, 2010 Oct 27 , 170, 692-702

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20682332


Abstract
Large conductance Ca(2+)-activated potassium (BK) channels play important roles in controlling neuronal excitability. We cloned the PISlo gene encoding BK channels from the spiny lobster, Panulirus interruptus. This gene shows 81-98% sequence identity to Slo genes previously found in other organisms. We isolated a number of splice variants of the PISlo cDNA within Panulirus interruptus nervous tissue. Sequence analysis indicated that there are at least seven alternative splice sites in PISlo, each with multiple alternative segments. Using immunohistochemistry, we found that the PISlo proteins are distributed in the synaptic neuropil, axon and soma of stomatogastric ganglion (STG) neurons.