PubMed 14657352

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav1.2 , Cav2.2 , Cav2.3

Title: CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.

Authors: Anne E Carlson, Ruth E Westenbroek, Timothy Quill, Dejian Ren, David E Clapham, Bertil Hille, David L Garbers, Donner F Babcock

Journal, date & volume: Proc. Natl. Acad. Sci. U.S.A., 2003 Dec 9 , 100, 14864-8

PubMed link:

CatSper family proteins are putative ion channels expressed exclusively in membranes of the sperm flagellum and required for male fertility. Here, we show that mouse CatSper1 is essential for depolarization-evoked Ca2+ entry and for hyperactivated movement, a key flagellar function. CatSper1 is not needed for other developmental landmarks, including regional distributions of CaV1.2, CaV2.2, and CaV2.3 ion channel proteins, the cAMP-mediated activation of motility by HCO3-, and the protein phosphorylation cascade of sperm capacitation. We propose that CatSper1 functions as a voltage-gated Ca2+ channel that controls Ca2+ entry to mediate the hyperactivated motility needed late in the preparation of sperm for fertilization.