Referenced in: none

Automatically associated channels: ClC3 , ClC4

Title: Expression of chloride channel protein CLC-3 in patients with allergic rhinitis: effect of topical corticosteroid treatment.

Authors: Huabin Li, Weiping Wen, Lei Cheng, Jianbo Shi, Hongyan Jiang, Yun Oh, Geng Xu

Journal, date & volume: Arch. Otolaryngol. Head Neck Surg., 2008 Mar , 134, 301-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18347257

Abstract
To determine whether the chloride channel protein CLC-3 is upregulated in patients with allergic rhinitis (AR) and whether topical corticosteroid treatment decreases the expression of CLC-3.Histologic study.Academic research.Eighteen patients with AR were included in the study.Expression of CLC-3 was detected by immunohistochemistry and by reverse transcription-polymerase chain reaction before and at 4 weeks after treatment with the topical corticosteroid mometasone furoate.Strong CLC-3 expression was detected in epithelium and in submucosal glands. An increased presence of CLC-3 was demonstrated in nasal mucosa compared with that in normal nasal tissue. A statistically significant difference in CLC-3 gene expression level was found in nasal tissues before vs at 4 weeks after treatment with mometasone.CLC-3 may have a role in modulating the pathogenesis of AR. Decreased expression of CLC-3 may be the mechanism of action of corticosteroid treatment in controlling AR.