Referenced in: none

Automatically associated channels: Cav1.2

Title: Neuroprotective effects of NBQX on hypoxia-induced neuronal damage in rat hippocampus.

Authors: Y Matsuoka, Y Kitamura, T Tsukahara, K Terai, I Tooyama, H Kimura, T Taniguchi

Journal, date & volume: Neuroreport, 1995 Nov 13 , 6, 2205-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8595203

Abstract
Models of cerebral ischaemia were used for analysis of mechanism of neuronal cell death and/or damage. Ischaemia is caused dominantly by severe hypoxia and hypoglycaemia: in the present study, we examined the influence of severe in vivo hypoxia (5% O2/95% N2 for 30 min at 22 degrees C). After hypoxia, neuronal damage was observed in the CA3 and dentate gyrus (DG) after 3 and 21 days of survival, but not in the CA1.2,3-Dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline (NBQX), an antagonist for AMPA/kainate receptors, showed neuroprotective effects in the CA3 and DG. These results suggest that hypoxia may induce neuronal damage in the CA3 and DG through activation of AMPA/kainate receptors.