PubMed 10840395

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: BK

Title: Changes in benzodiazepine binding in a subkindling situation.

Authors: A S Rössler, J M Launay, P Venault, R H Dodd, G Chapouthier

Journal, date & volume: Epilepsia, 2000 Jun , 41, 651-4

PubMed link:

A low dose of the benzodiazepine receptor inverse agonist methyl beta-carboline-3-carboxylate (beta-CCM) (1 mg/kg) was used to assess [3H]-flumazenil binding in a subkindling situation in Swiss mice.The brains were removed, and benzodiazepine receptor binding was studied every second day over 14 days of administration.With each successive trial, Bmax values showed a steady and significant decrease, whereas Kd values showed a steady and significant increase. Behavioral data showed that at this low dose, actual kindling (seizuring) was not reached at the behavioral level.The findings suggest that decreased gamma-aminobutyric acid (GABA) inhibition may occur even if behavioral effects of kindling are not observed.