Referenced in: none

Automatically associated channels: Kir2.3

Title: On-bipolar cells and depolarising third-order neurons as the origin of the ERG-b-wave in the RCS rat.

Authors: K Wurziger, T Lichtenberger, R Hanitzsch

Journal, date & volume: Vision Res., 2001 Apr , 41, 1091-101

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11301082

Abstract
In the retinas of Royal College of Surgeons (RCS) rats light induces an increase in distal extracellular potassium irrespective of the age, between days 19-24 and days 29-35 postpartum, but by days 29-35 the ERG b-wave has become reduced. The synaptic blocker 2-amino-4-phosphonobutyric acid (APB) causes the abolition of both the b-wave and the potassium increase at any age. MgCl2 greatly reduces the b-wave at all ages and abolishes the potassium increase in older rats, but in younger rats the potassium increase is enlarged. Since this increase occurs in the absence of the b-wave it is unlikely that the on-bipolar cells are the only sources of the b-wave. Because the NMDA receptor blocker ketamine reduces the b-wave, third order neurons, which possess NMDA receptors, could contribute to the b-wave.