Channelpedia

PubMed 16393881


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: SK3



Title: Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population.

Authors: M Ivković, V Ranković, A Tarasjev, S Orolicki, A Damjanović, V R Paunović, S Romac

Journal, date & volume: Int. J. Neurosci., 2006 Feb , 116, 157-64

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16393881


Abstract
KCNN3 might be a candidate gene for schizophrenia. The KCNN3 cDNA sequence contains two stretches of CAG trinucleotide repeats encoding two separate polyglutamine segments near the N-terminus of this channel protein. The second CAG repeat is highly polymorphic in the Caucasian population from both Europe and United States. The authors carried out a study to compare the allelic frequency distribution of the CAG repeat in KCNN3 gene in 55 Serbian schizophrenic patients and 46 controls. The data indicate a significant association between longer CAG repeats in second polymorphic KCNN3 region and schizophrenia in the Serbian population.