Channelpedia

PubMed 11711128


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: BK



Title: Identification of bradykinins in solitary wasp venoms.

Authors: Katsuhiro Konno, Mario Sérgio Palma, Izaura Yoshico Hitara, Maria Aparecida Juliano, Luiz Juliano, Tadashi Yasuhara

Journal, date & volume: Toxicon, 2002 Mar , 40, 309-12

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11711128


Abstract
Bradykinins were identified in three solitary wasp venoms. Purification and characterization of the venom extract of the scoliid wasp Megacampsomeris prismatica led to the identification of bradykinin and threonine(6)-bradykinin as the major peptide components. The survey of a number of extracts from solitary wasp venom by MALDI-TOF MS revealed that the venoms of two other scoliid wasps, Campsomeriella annulata annulata and Carinoscolia melanosoma fascinata, also contained Thr(6)-BK as one of the major components. Thus, this study showed the presence of bradykinins in some of the solitary wasp venoms. Moreover, it indicated that these peptides play a major role in their paralyzing action for prey capture because these bradykinins have been shown to block the synaptic transmission of the nicotinic acetylcholine receptor in the insect central nervous system.