Channelpedia

PubMed 17631373


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.4 , Kv3.1 , Kv4.1 , Kv4.2 , Kv4.3



Title: Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels.

Authors: Chunhua Yuan, Zhi Liao, Xiongzhi Zeng, Longjun Dai, Fang Kuang, Songping Liang

Journal, date & volume: Toxicon, 2007 Oct , 50, 646-52

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17631373


Abstract
Jingzhaotoxin-XII (JZTX-XII), a 29-residue polypeptide, was purified from the venom of the Chinese tarantula Chilobrachys jingzhao. Electrophysiological recordings carried out in Xenopus laevis oocytes showed that JZTX-XII is specific for Kv4.1 channels, with the IC50 value of 0.363 microM. It interacts with the channels by modifying the gating behavior. JZTX-XII shares 80% sequence identity with phrixotoxin1, a potent inhibitor for Kv4.2 and Kv4.3 channels. Structure analysis indicates that the difference of the charge distribution in the interactive surface perhaps influences the specific pharmacology of the toxins. JZTX-XII should be a valuable tool for the investigation of the Kv4.1 channels.