Referenced in: none

Automatically associated channels: SK1 , SK2 , SK3

Title: SK channels are on the move.

Authors: V Seutin, J-F Liégeois

Journal, date & volume: Br. J. Pharmacol., 2007 Jul , 151, 568-70

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17486139

Abstract
Small-conductance Ca(2+)-activated K(+) channels (SK channels) underlie the medium duration after hyperpolarization that follows single or trains of action potentials in many types of neurons. Three subtypes of SK subunits, SK1 (K(Ca)2.1), SK2 (K(Ca)2.2) and SK3 (K(Ca)2.3), have been cloned and are expressed differentially within the central nervous system (CNS). A paper in this issue of BJP reports the discovery of the first example of a positive modulator displaying not only selectivity for SK channels over other channels, but also a subtype selectivity among SK and analogous channels (SK3>SK2>>>SK1=IK). Together with other recent progress in the field, this finding enriches the repertoire of tools available to test the hypothesis that SK channels may be targets for future CNS drugs.