Referenced in: none

Automatically associated channels: Nav1.8

Title: Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis.

Authors: Shu-Wei Yang, Tze-Ming Chan, Alexei Buevich, Tony Priestley, James Crona, John Reed, Amy E Wright, Mahesh Patel, Vincent Gullo, Guodong Chen, Birendra Pramanik, Min Chu

Journal, date & volume: Bioorg. Med. Chem. Lett., 2007 Oct 15 , 17, 5543-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17804230

Abstract
Bioassay-guided fractionation of an active fraction from an extract of a marine starfish, Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (1) and Sch 725739 (2). Compound 1 was identified as the NaV1.8 inhibitor with IC(50) of approximately 9 microM. The purification and the structure elucidation of these two saponins are described.