Channelpedia

PubMed 17197081


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.4 , Kv3.1



Title: Delta opioids reduce the neurotransmitter release probability by enhancing transient (KV4) K+-currents in corticostriatal synapses as evaluated by the paired pulse protocol.

Authors: Xochitl Jose, Juan Carlos Pineda, Cynthia Rodriguez, Ernesto Mendoza, Elvira Galarraga, José Bargas, Jaime Barral

Journal, date & volume: Neurosci. Lett., 2007 Mar 6 , 414, 150-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17197081


Abstract
Field recordings were used to determine the influence of delta-opioid receptor activation on corticostriatal synaptic transmission. Application of the selective delta-opioid receptor agonist, [Tyr-D-Pen-Gly-Phe-D-Pen]-enkephalin (DPDPE, 1 microM), decreased the amplitude of the field-excitatory synaptic potential and at the same time increased the paired pulse ratio (PPR) suggesting a presynaptic site of action. This response reversed rapidly when DPDPE was washed and blocked by 1 nM of the selective delta-receptor antagonist naltrindole. Neither omega-conotoxin GVIA (1 microM) nor omega-agatoxin TK (400 nM), blockers of N- and P/Q-type Ca2+-channels, respectively, nor TEA (1 mM), blocker of some classes of K+-channels, occluded the effects of DPDPE. Instead, 1 mM 4-AP or 400 microM Ba2+ occluded completely the effects of DPDPE. Therefore, the results suggest that the modulation by delta opioids at corticostriatal terminals is mediated by transient (KV4) K+-conductances.