Referenced in: none

Automatically associated channels: Cav3.1 , Slo1

Title: Monovalent currents through the T-type Cav3.1 channels and their block by Mg2+.

Authors: M Kurejová, M Pavlovicová, L' Lacinová

Journal, date & volume: Gen. Physiol. Biophys., 2007 Sep , 26, 234-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18063852

Abstract
We have investigated the permeability of the Cav3.1 channel for Ca2+ and different monovalent cations and the block of the currents by Mg2+ ions. In the absence of extracellular divalent cations, the Cav3.1 channel was more permeable for Na+ than for Cs+ and impermeable for NMDG+. Monovalent currents were inhibited by Mg2+ of near physiological concentration by three orders of magnitude more effectively than the Ca2+ current. Inhibition of outward, but not inward current by Mg2+ was voltage-dependent. Furthermore, magnesium slowed down channel deactivation presumably by interacting with an open channel state.