PubMed 17668386

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir1.1 , Kir6.2

Title: Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects.

Authors: Sian Ellard, Sarah E Flanagan, Christophe A Girard, Ann-Marie Patch, Lorna W Harries, Andrew Parrish, Emma L Edghill, Deborah J G Mackay, Peter Proks, Kenju Shimomura, Holger Haberland, Dennis J Carson, Julian P H Shield, Andrew T Hattersley, Frances M Ashcroft

Journal, date & volume: Am. J. Hum. Genet., 2007 Aug , 81, 375-82

PubMed link:

Heterozygous activating mutations in the KCNJ11 gene encoding the pore-forming Kir6.2 subunit of the pancreatic beta cell K(ATP) channel are the most common cause of permanent neonatal diabetes (PNDM). Patients with PNDM due to a heterozygous activating mutation in the ABCC8 gene encoding the SUR1 regulatory subunit of the K(ATP) channel have recently been reported. We studied a cohort of 59 patients with permanent diabetes who received a diagnosis before 6 mo of age and who did not have a KCNJ11 mutation. ABCC8 gene mutations were identified in 16 of 59 patients and included 8 patients with heterozygous de novo mutations. A recessive mode of inheritance was observed in eight patients with homozygous, mosaic, or compound heterozygous mutations. Functional studies of selected mutations showed a reduced response to ATP consistent with an activating mutation that results in reduced insulin secretion. A novel mutational mechanism was observed in which a heterozygous activating mutation resulted in PNDM only when a second, loss-of-function mutation was also present.