Referenced in: none

Automatically associated channels: Kv1.5 , Kv11.1

Title: Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel.

Authors: Michael F Gross, Serge Beaudoin, Grant McNaughton-Smith, George S Amato, Neil A Castle, Christine Huang, Anruo Zou, Weifeng Yu

Journal, date & volume: Bioorg. Med. Chem. Lett., 2007 May 15 , 17, 2849-53

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17350840

Abstract
A collection of aryl sulfonamido indanes based on the lead compound 1 was synthesized and evaluated for Kv1.5 inhibitory activity. Kv1.5 inhibitors have the potential to be atrium-selective agents for treatment of atrial fibrillation. (1R,2R)-1 has an IC(50) of 0.033microM against Kv1.5 and is selective against other cardiac ion channels, including hERG.