Referenced in: none

Automatically associated channels: Cav1.2

Title: Regulation of Cav1.2 current: interaction with intracellular molecules.

Authors: Takeshi Kobayashi, Yoichi Yamada, Mitsuhiro Fukao, Masaaki Tsutsuura, Noritsugu Tohse

Journal, date & volume: J. Pharmacol. Sci., 2007 Apr , 103, 347-53

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17409629

Abstract
Ca(V)1.2 (alpha(1c)) is a pore-forming subunit of the voltage-dependent L-type calcium channel and is expressed in many tissues. The beta and alpha(2)/delta subunits are auxiliary subunits that affect the kinetics and the expression of Ca(V)1.2. In addition to the beta and alpha(2)/delta subunits, several molecules have been reported to be involved in the regulation of Ca(V)1.2 current. Calmodulin, CaBP1 (calcium-binding protein-1), CaMKII (calcium/calmodulin-dependent protein kinase II), AKAPs (A-kinase anchoring proteins), phosphatases, Caveolin-3, beta(2)-adrenergic receptor, PDZ domain proteins, sorcin, SNARE proteins, synaptotagmin, CSN5, RGK family, and AHNAK1 have all been reported to interact with Ca(V)1.2 and the beta subunit. This review focuses on the effect of these molecules on Ca(V)1.2 current.