PubMed 20650701

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: BK

Title: Hyperpolarization of human mesenchymal stem cells in response to magnetic force.

Authors: Glen R Kirkham, Kerry J Elliot, Ahmed Keramane, Donald M Salter, Jon P Dobson, Alicia J El Haj, Sarah Harriet Cartmell

Journal, date & volume: IEEE Trans Nanobioscience, 2010 Mar , 9, 71-4

PubMed link:

Magnetic particle tagging techniques are currently being applied to tissue engineering applications such as controlled differentiation of mesenchymal stem cells (MSC). In order to define key mechanotransducers underpinning these applications, the electrophysiological responses of human MSCs (hMSC) have been investigated. Ferromagnetic microparticles were coated with L-arginyl-glycyl-L-aspartic acid in order to target the application of dynamic force (6 pN) directly to cell surface integrins. Human MSCs demonstrated cell membrane hyperpolarization responses after the application of force, mediated by BK channels and intracellular calcium release.