Referenced in: none

Automatically associated channels: BKβ , Slo1

Title: Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists.

Authors: Vijay K Gore, Vu V Ma, Ruoyuan Yin, Joe Ligutti, David Immke, Elizabeth M Doherty, Mark H Norman

Journal, date & volume: Bioorg. Med. Chem. Lett., 2010 Jun 15 , 20, 3573-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20493696

Abstract
The membrane bound large-conductance, calcium-activated potassium channel (BKCa) is an important regulator of neuronal activity. Here we describe the identification and structure-activity relationship of a novel class of potent tetrahydroquinoline BKCa agonists. An example from this class of BKCa agonists was shown to depress the spontaneous neuronal discharges in an electrophysiological model of migraine.