Referenced in: none

Automatically associated channels: Kv10.1 , Kv6.1

Title: Sp-tetraKCNG: A novel cyclic nucleotide gated K(+) channel.

Authors: Blanca Estela Galindo, José Luis de la Vega-Beltrán, Pedro Labarca, Victor D Vacquier, Alberto Darszon

Journal, date & volume: Biochem. Biophys. Res. Commun., 2007 Mar 16 , 354, 668-75

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17254550

Abstract
The sequence of a novel cGMP-regulated, tetrameric, K(+) selective channel (Sp-tetraKCNG) was discovered in the sea urchin Strongylocentrotus purpuratus. The Sp-tetraKCNG is a single polypeptide made of four KCNG domains similar to voltage-dependent Na(+) and Ca(2+) channels. Each KCNG domain has six transmembrane segments (S1-S6), the ion pore having the K(+) selectivity signature GYGD and a cyclic nucleotide-binding domain (CNBD). This novel channel is evolutionary located between K(+)-selective and voltage-dependent EAG channels and voltage-independent cationic CNG channels. Bilayer reconstitutions demonstrate such a cGMP-regulated K(+) selective channel in sea urchin spermatozoa.