Referenced in: none

Automatically associated channels: Cav2.3 , SK3

Title: Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells.

Authors: Marie Potier, Truong An Tran, Aurelie Chantome, Alban Girault, Virginie Joulin, Philippe Bougnoux, Christophe Vandier, Fabrice Pierre

Journal, date & volume: Biochem. Biophys. Res. Commun., 2010 Jun 18 , 397, 42-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20519134

Abstract
Lost of adenomatous polyposis coli gene (Apc) disturbs the migration of intestinal epithelial cells but the mechanisms have not been fully characterized. Since we have demonstrated that SK3/KCa2.3 channel promotes cancer cell migration, we hypothesized that Apc mutation may affect SK3/KCa2.3 channel-mediated colon epithelial cell motility. We report evidence that SK3/KCa2.3 channel promotes colon epithelial cells motility. Following Apc mutation SK3/KCa2.3 expression is largely reduced leading to a suppression of the SK3/KCa2.3 channel mediated-cell migration. Our findings reveal a previously unknown function of the SK3/KCa2.3 channel in epithelial colonic cells, and suggest that Apc is a powerful regulator SK3/KCa2.3 channel.