Referenced in: none

Automatically associated channels: Kv1.5

Title: Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers.

Authors: John Lloyd, Heather J Finlay, Wayne Vacarro, Tram Hyunh, Alexander Kover, Rao Bhandaru, Lin Yan, Karnail Atwal, Mary Lee Conder, Tonya Jenkins-West, Hong Shi, Christine Huang, Danshi Li, Huabin Sun, Paul Levesque

Journal, date & volume: Bioorg. Med. Chem. Lett., 2010 Feb 15 , 20, 1436-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20097068

Abstract
Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.