Referenced in: none

Automatically associated channels: KChIP2 , Kv1.4 , Kv3.1 , Kv4.3

Title: [Atrial myocytes KChIP2 mRNA expression in rheumatic heart disease patients with atrial fibrillation]

Authors: Xiao-qiu Tan, Yan Yang, Zhi-Fei Liu, Zhi-ru Bai, Wen Zhou, Jie Pei, Gui-Lan Chen, Xiao-Rong Zeng

Journal, date & volume: Zhonghua Xin Xue Guan Bing Za Zhi, 2009 Jun , 37, 509-13

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19927631

Abstract
To detect the KChIP2 mRNA level in rheumatic heart disease patients with or without atrial fibrillation (AF) by real-time PCR.Right atrial appendage samples from rheumatic heart disease patients with (n = 17) or without AF (n = 13) were obtained during cardiac surgery. Total RNA was extracted from the atrial tissues, and the KChIP2 and Kv4.3 mRNA were detected by SYBR Green I real-time PCR with the GAPDH as the house keeping gene.The ratio of KChIP2/GAPDH (0.1468 +/- 0.0452 vs. 0.2200 +/- 0.0388, P<0.01) and the ratio of Kv4.3/GAPDH (0.3946 +/- 0.1826 vs. 0.5257 +/- 0.1427, P<0.05) were significantly lower in AF patients compared to non-AF patients.Down-regulated atrial KChIP2 and Kv4.3 mRNA expressions in rheumatic heart disease patients with chronic AF might be one of the molecular bases responsible for the down-regulation of the I(to) current density of AF.