Channelpedia

PubMed 19607836


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir1.1 , Kir6.1 , Kir6.2



Title: Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!

Authors: Haixia Zhang, Thomas P Flagg, Colin G Nichols

Journal, date & volume: J. Mol. Cell. Cardiol., 2010 Jan , 48, 71-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19607836


Abstract
Reconstitution of K(ATP) channel activity from coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein sub-family, has led to the elucidation of many details of channel gating and pore properties, as well as the essential roles of Kir6.2 and SUR2 subunits in generating cardiac ventricular K(ATP). However, despite this extensive body of knowledge, there remain significant holes in our understanding of the physiological role of the cardiac K(ATP) channel, and surprising new findings keep emerging. Recent findings from genetically modified animals include the apparent insensitivity of cardiac sarcolemmal channels to nucleotide levels, and unenvisioned complexities of the subunit make-up of the cardiac channels. This topical review focuses on these new findings and considers their implications.